High Sensitive CRP (ULTRASENSITIVE)
C- Reaction Protein (CRP), which is synthesized in the liver, is one of the most sensitive acute phase reactants. After tissue damage or inflammation CRP activates the classical complement pathway as a response to the inflammatory reaction.
CRP levels in serum can rise dramatically after myocardial infarction, stress trauma, infection inflammation, surgery or neoplastic proliferation.
The increase occurs within 24 to 48 hours and the level may be up to 2000 times normal. An elevation can be expected in virtually all diseases involving tissue damages, so the finding is nonspecific.
Elevations of CRP levels within the conventional reference range have been reported in several studies. These studies have shown that high sensitive CRP (HsCRP) is of interest in predicting the risk for future cardiovascular events and peripheral vascular diseases. Concentrations greater than 10 mg/L generally have a significant other inflammatory process occurring.
Clinical diagnosis should not be made on the findings of a single test result, but should integrate both clinical and laboratory data.
Reference Range: < 5 mg/L
Relative risk of myocardial infarct (after exclusion of an inflammatory process):
CRP (mg/L) risk
</= 0.55 : 1.0
0.56-1.14 : 1.1-2.9
1.15-2.10 : 1.6-4.3
>/=2.11 : 1.8-4.6