The goal of Saridar Lab is the development of non - invasive diagnostic tests which aim to improve the management of liver disease and that can achieve a 50% reduction in number of required liver biopsies.
Fibro-Max is actually five tests all in one:
1) Fibro Test
Non invasive alternative to measure fibrosis in patients with chronic hepatitis C or B, alcoholic liver disease and metabolic steatosis:
F0 : No Fibrosis
F1 : Portal Fibrosis
F2 : Bridging Fibrosis with Few Septa
F3 : Bridging Fibrosis with Many Septa
F4 : Cirrhosis
2) Acti Test
The Acti Test offers a non invasive alternative to measure necro-inflammatory activity in patients with chronic hepatitis C or B:
A0 : No activity
A1 : Minimal Activity
A2 : Moderate Activity
A3 : Severe Activity
3) Steato Test
The Steato Test offers a non invasive alternative to measure hepatic steatosis (triglyceride deposits in the liver) in patients with chronic hepatitis C or B, alcoholic liver disease and metabolic steatosis (overweight, diabetes, hyperlipidemia):
S0: No steatosis
S1: Minimal steatosis, less than 5% of hepatocytes with steatosis
S2: Moderate steatosis, between 6-32% of hepatocytes with steatosis
S3: Severe steatosis, between 33-100% of hepatocytes with steatosis
4) Nash Test
The Nash Test offers a non invasive alternative to diagnose non alcoholic steato hepatitis (NASH) in patients with metabolic steatosis (overweight, diabetes and hyperlipidemia):
N0 : No Nash
N1 : Borderline
N2 : Nash
5) Ash Test
The Ash Test offers a non invasive alternative to measure alcoholic steato hepatitis (ASH) in patients with alcoholic liver disease:
H0 : No Ash
H1 : Minimal Ash
H2 : Moderate Ash
H3 : Severe Ash
What are the most frequent causes of false positive results for Fibro test & Acti Test?
· Haemolysis, which decreases haptoglobin as observed with ribavirin treatment, or cardiac prosthesis.
· Gilbert syndrome, which increases total bilirubin.
· Extra-hepatic cholestasis, which increases GGT and total bilirubin.
· Drugs which increase total bilirubin as atazanavir.