Type (I) D.M. and Its Relation to Celiac Disease and Autoimmune Thyroid Disease
In type (I) D.M., the coexistence of other endocrine diseases and organ specific autoantibodies has been frequently reported, leading to the concept of autoimmune polyendocrine syndrome.
There is ample and convincing evidence for the autoimmune pathogenesis of type (I) D.M., e.g. inflammatory infiltration of the pancreas with T lymphocytes (insulitis), association with other autoimmune disorders, antibodies (ICA, IAA, GAD), and changes in cellular immunity.
The prevalence of celiac disease in patients with type (I) D.M. is approximately 20-fold that in the general population.
IgA antibodies against tissue transglutaminase were found in 1.0